About

The BC Proteomics Network is led by a Scientific Director with the assistance of three Co-Leaders who are part of an  Executive Committee which functions the main governing body of the network.  

 

Executive Commitee

Thibault Mayor
BCPN Scientific Director
Associate Professor, UBC Biochemistry & Molecular Biology

Christoph Borchers
BCPN Co-Leader
Director, University of Victoria Genome BC Proteomics Centre

Gregg Morin
BCPN Co-Leader
Head of Proteomics, Genome Sciences Centre, BC Cancer Agency

Chris Overall
BCPN Co-Leader
Canada Research Chair in Metalloproteinase Proteomics and Systems Biology, UBC

Juergen Kast
Biomedical Research Centre, UBC

Bruce McManus
Director, UBC James Hogg Research Centre

George Agnes
Professor, Chemistry, SFU

Vincent Duronio
Professor, Medicine, UBC

Leonard Foster
Professor, Biochemistry & Molecular Biology, UBC

 

Research Areas

There are currently over 60 faculty members who are affiliated with the BC Proteomics Network. These investigators are involved in diverse research activities and are located at institutions across the province including the University of British Columbia, Simon Fraser University, University of Victoria, University of Northern British Columbia, BC Cancer Agency and the research hospitals.

Research Areas

Proteomics Research

George Agnes
Associate Professor, Chemistry SFU
Home Page
analysis of biomolecules in suspended droplets by MS; investigation of biological compounds at sub-nanomolar concentrations in physiological fluids
Christoph Borchers
Director, UVic Genome BC Proteomics Centre UVic
Home Page
protein and biomarker discovery & validation; quantitative proteomics; metabolomics; structural proteomics; MALDI imaging
John Burke
Assistant Professor, Biochemistry & Microbiology UVic
Home Page
structural mass spectrometry, lipid phosphoinositides
Leonard Foster
Associate Professor, Biochemistry & Molecular Biology UBC
Home Page
quantitative proteomics techniques; host pathogen interactions; lipid raft composition; proteomics software tools
Juergen Kast
Associate Professor, Chemistry UBC
Home Page
MS techniques for post-translational modification, protein-protein interaction, quantitation and localization; signal transduction in immune cells
Philipp Lange
Assistant Professor
Pathology UBC
Home Page
molecular basis of childhood cancer
Thibault Mayor
Assistant Professor, Biochemistry & Molecular Biology UBC
Home Page
proteomic techniques to analyze post-translational modifications; ubiquitin and proteasome systems
Gregg Morin
Head, Proteomics, Genome Sciences Centre BC Cancer Agency
Home Page
target identification & validation; functional analysis of tumor promoting proteins; post-translational modifications; protein-protein interactions
Chris Overall
Professor, Biochemistry & Molecular Biology UBC
Home Page
protease degradomes; matrix metalloproteinase substrates
Bingyun Sun
Assistant Professor, Chemistry
SFU
Home Page
mass spectrometry and nanobiotechnology based techniques for quantitative functional proteomics
David Vocadlo
Assistant Professor, Chemistry SFU
Home Page
post-translational glycosylation of nuclear and cytoplasmic proteins; proteomic techniques for the study of intracellular glycosylation

Bioinformatics

Steve Jones
Senior Scientist
Genome Sciences Centre, BCCA
Home Page
expression profiling techniques to understand expression changes in cancer; bioinformatics
Raymond Ng
Professor
Computer Science, iCAPTURE
Home Page
data mining, bioinformatics
Frederic Pio
Associate Professor
Molecular Biology & Biochemistry, SFU
Home Page
structural bioinformatics
Chris Upton
Professor
Biochemistry & Microbiology, UVic
Home Page
viral bioinformatics

Clinical Research

Pascal Bernatchez
Assistant Professor
Pharmacology, UBC
Home Page
molecular characterization of endothelial dysfunction and angiogenesis
Mari DeMarco
Clinical Assistant Professor Pathology & Laboratory Medicine UBC
Home Page
method development for clinical diagnostics, clinical proteomics, amyloidosis & neurodegeneration
Emma Guns
Associate Professor
Urologic Sciences, UBC
Home Page
prostate tumor models, pharmacokinetic analysis
David Huntsman
Associate Professor
Pathology & Laboratory Medicine, BCCA
Home Page
hereditary gastric cancer; development of predictive and prognostic tissue-based cancer biomarkers
Paul Keown
Head
Nephrology, VGH
Home Page
immune response in transplantation and autoimmune disease
Bruce McManus
Director, iCAPTUREHome Page
transplantation biomarkers of heart and lung
Rob McMaster
Head
Medical Genetics, UBC
Home Page
molecular immunology, transplant immunology & immunogenetics; host-pathogen interactions; quantitative plasma proteomic biomarker discovery
Geoff Payne
Assistant Professor
Physiology, UNBC
Home Page
vascular immunology, impact of diseases on microcirculation
Bill Salh
Associate Professor, Medicine
inflammatory bowel disease; gastrointestinal cancer; PI3K and MAPK signaling
Scott Tebbutt
Assistant Professor
UBC, PROOF Centre of Excellence
Home Page
genetics of complex respiratory disease; rapid genome-based diagnostics

Infectious Disease

Yossef AvGay
Professor
Medicine, UBC
Home Page
molecular pathogenesis of Mycobacterium tuberculosis
Horacio Bach
Adjunct Professor Medicine
UBC
Home Page
pathogenic virulence factors, nanomedicine, antibody engineering
Caroline Cameron
Associate Professor
Biochemistry & Microbiology, UVic
Home Page
adhesin involvement in Treponema pallidum; proteomic analysis of Leptospira
Francois Jean 
Associate Professor Microbiology & Immunology, UBC
Home Page
developement of tools for studying viral-host cell interactions; development of antiviral agents

Technology and Drug Development

Carl Hansen
Assistant Professor
Physics UBC
Home Page
development of tools for single cell manipulation, protein interaction and molecular diagnostics, and microfluidic based structural biology
Fraser Hof
Associate Professor
Chemistry UVic
Home Page
medicinal and supramolecular chemistry
Andre Marziali
Associate Professor
Biophysics, UBC
Home Page
development of new technologies and instrumentation for genomics
Mario Pinto
VP Research
Professor, Chemistry, SFU
Home Page
nature and origin of carbohydrate mimicry for the purpose of drug and vaccine design
Paul Shipley
Assistant Professor
Chemistry, UBC Okanagan
Home Page
Streptomyces secondary metabolism; development of new pharmacologically active compounds
Robert Young
Professor
Chemistry, SFU
Home Page
design and synthesis of small molecule probes for target discovery and validation; development of drug candidates

Molecular & Cell Biology

Juan Ausio
Professor
Biochemistry & Microbiology, UVic
Home Page
structural characterization of biological molecular assemblies; nuclear proteins; chromatin epigenetics
Clare Beasley
Assistant Professor
Brain Research Centre, UBC
Home Page
molecular mechanisms of psychosis
Harry Brumer
Professor
Michael Smith Laboratories, UBC
Home Page
fundamental and applied carbohydrate enzymology, including enzyme discovery and characterization
Robert Burke
Professor and Chair
Biochemistry & Microbiology, UVic
Home Page
molecular characterization of early development mechanisms
Dave Clarke
Assistant Professor, Biomedical Physiology & Kinesiology, SFU Home Page
quantitative studies of exercise biology
Claire Cupples
Professor
Biochemistry & Molecular Biology, SFU
Home Page
DNA repair mechanisms, Tetrahymena genetics
Max Cynader
Director
Brain Research Centre, UBC
Home Page
molecular mechanisms of neuronal plasticity and cell death
Caigan Du
Assistant Professor
Urologic Sciences UBC
Home Page
molecular mechanisms of kidney injury following ischemia-reperfusion and transplant rejection
Vincent Duronio
Professor
Medicine, UBC
Home Page
biochemical signals which control cell death and survival; role of macrophages in development of atherosclerosis; response of inflammatory cells to infection
Adam Frankel
Assistant Professor
Pharmaceutical Sciences UBC
Home Page
Role of protein arginine N-methyltransferases in cancer progression
Norbert Haunerland
Professor
Biological Sciences, SFU
Home Page
fatty acid mediated gene control; lipid transport and metabolism in insects
Phil Hieter
Director
Michael Smith Laboratories, UBC
Home Page
molecular biology of eukaryotic chromosome transmission
Perry Howard
Associate Professor
Biochemistry & Microbiology, UVic
Home Page
signal transduction mechanisms of cancer cells and Eph receptors
Aly Karsan
Senior Scientist
Medical Biophysics, BCCA
Home Page
TLR and Notch pathways in myelodyplastic syndromes and the role of the endothelium in development of the hematopoietic system
Yvonne Lamers
Assistant Professor
Land and Food Systems UBC
Home Page
B vitamins in human metabolism
Chow Lee
Associate Professor
Biochemistry & Molecular Biology, UNBC
Home Page
post-transcriptional regulation of mammalian gene expression
Ross MacGillivray
Director
Centre for Blood Research, UBC
Home Page
human blood proteins involved in coagulation and iron hemostasis
Christopher Nelson
Assistant Professor
Biochemistry & Microbiology, UVic
Home Page
post-translational modifications of histone proteins
Steven Pelech
Professor
Medicine, UBC
Home Page
protein kinase based cell signaling pathways for neurological disorders, cancer and diabetes
Stephen Rader
Assistant Professor
Chemistry, UNBC
Home Page
mechanisms of pre-messenger RNA splicing
Marianne Sadar
Senior Scientist
Genome Sciences Centre, BC Cancer Agency
Home Page
molecular mechanisms of tumor progression and emergence of hormone independence in prostate cancer
John Schrader
Director, BRC, UBC
Home Page
role of Ras in signal transduction mechanisms of immune cells; use of antibodies as therapeutics
Leigh Anne Swayne
Assistant Professor
Medical Sciences UVic
Home Page
regulation of ion channels, role of ion channels in cell signaling, pannexins, NALCN, voltage-gated calcium channels
Steve Withers
Professor
Chemistry, UBC
Home Page
biochemical study of enzymes which catalyze glycoside hyrolysis and other glycosyl transfers
Kirsten Wolthers
Assistant Professor
Chemistry
UBC Okanagan
Home Page
dynamics of enzyme catalysis, radical based biocatalysts
Wesley Zandberg
Assistant Professor
Chemistry
UBC Okanagan
Home Page
protein glycosylation and protein structure and function

Plant & Animal Research

Brian Ellis
Professor
Michael Smith Laboratories, UBC
Home Page
plant protein kinase signaling pathways
Caren Helbing
Associate Professor
Biochemistry & Microbiology, UVic
Home Page
use of sentinel species as indicators for endocrine disruptors; cellular mechanisms of amphibian metamorphosis
Dezene Huber
Assistant Professor
Ecosystems Science & Management, UNBC
Home Page
interactions between insects and plants; defense mechanisms against mountain pine beetles
Susan Murch
Associate Professor
Chemistry, UBC Okanagan
Home Page
plant metabolomics; investigating neurochemicals in plants; physiology and biochemistry of medicinal plants
Patrick von Aderkas
Professor
Biology, UVic
Home Page
metabolomics of hormones in plants; reproductive biology of conifers

There are three major mass spectrometry core facilities available in BC.

UVic Genome BC Proteomics Centre
UBC Proteomics Core Facility Centre
BC Genome Sciences Centre

Mass spectrometry instruments are also located in several laboratories at UBC, SFU and the research hospitals.